We were put into this world to accomplish. Each of us has a unique mission. There are many different forms of personal achievement, just as there are different people on our planet.
Make it a regular habit to imagine yourself accomplishing what you wish to accomplish. This will motivate yourself to accomplish more. As you create these visions in your mind's eye, you will be conditioning yourself in a way that - in reality - will lead to many positive accomplishments.
Love Yehuda Lave
I returned August 15 to Jerusalem after a 16 day absence from Israel. I visited over 100 synagogues, graves and holy spots throughout Czech and Vienna, along with castles and tourist spots. My friend the Cabalist, says like the Bal Shem Tov, I was gathering up the holy sparks of Jewishness that has been trapped there and bringing the spiritual energy back to Jerusalem. I hope I have accomplished that goal, but I know for sure that I brought back lots of pictures. There are too many to share at one time so I am trying something new and sharing them day by day as experienced with a 16 day delay. I will repeat this introduction each day. I have been studying Jewish history and Israel in my time in Jerusalem, but the history of the Jewish people in modern times from 1492 to 1945 was in central Europe where the majority of the Jewish people lived. It is worth studying and knowing about and by sharing it with you my friends, I hope I am expanding your knowledge as well.
Quotes from my sister Heather
It's no wonder that truth is stranger than fiction. Fiction has to make sense. Mark Twain Samuel Langhorne Clemens, better known as Mark Twain, was an American author and humorist.
A lie gets halfway around the world before the truth has a chance to get its pants on. Winston Churchill Sir Winston Leonard Spencer-Churchill was a British politician
There's a world of difference between truth and facts. Facts can obscure the truth. Maya Angelou Poet
If you get stuck in a hole, you don't blame the hole. Bryce, the Shrink
Vienna Friday walk to the Opera House
If you will go in the way of My ordinances ... I will give your rain in the proper time (Leviticus 26:3-4).
Rashi explains that "going in the way of My ordinances" means that one will "toil in the Torah." This toil and labor itself causes the abundant blessings that follow.
Our culture highly values achievement, and it confers various kinds of reward for academic and scientific excellence. But the world is interested in results, not in the effort expended. If one person of limited capacity were to labor continuously at a given project without achieving success, while another person who is extremely gifted achieves success in the project with a minimum expenditure of effort, the latter will reap the reward. This is not the Jewish attitude. The Talmud states, "Reward is commensurate with effort." In the study of Torah, in the performance of mitzvos, and in the development of character, God measures virtue not by how much we accomplish, but by how hard we try.
The Talmud further states that not only are people rewarded for extreme effort; they are also blessed with those very goals for which they have worked. They receive not only the many material blessings listed in the chapter cited above, but also the spiritual goals for which they strove, and which might not have been attainable through human effort alone.
Today I shall ... ...
try to advance myself spiritually, and realize that God wants me to try - the reward will come from God.
Israeli corrective eye drops could make eyeglasses obsolete
Advanced eye drops may allow you to chuck your glassesTwo Israeli startups describe how their clinical-stage products could radically change the way people correct their vision. By Abigail Klein Leichman August
Would you rather wear glasses or contact lenses, have laser surgery, or put drops in your eyes to see well? Consumers are starting to demand the third option, as new scientific advances have made corrective eye drops possible.
This is big business: A couple of years ago, pharma giant Novartis acquired a company developing a topical treatment for age-related farsightedness (presbyopia), while others are experimenting with eye drops to dissolve cataracts.
In Israel, two startups are in the clinical stages of testing their corrective eye drops. ISRAEL21c asked them to explain how their different approaches could radically alter the way people improve their vision.
ORASIS: Goodbye, reading glasses
Orasis Pharmaceuticals of Herzliya recently raised $13 million to continue developing pharmaceutical-grade eye drops intended to improve near vision so people won't need their reading glasses.
CEO Elad Kedar says presbyopia affects the majority of people over age 45, giving Orasis a potential market of nearly 2 billion people around the globe; 120 million in United States.
"The lenses in our eyes, like any other organ, get old and gradually lose the flexibility to change shape to focus on near objects," Kedar says. "The reduction in flexibility makes it difficult to focus on near objects and eventually you need reading glasses."
Although reading glasses are effective, he continues, many people don't like using them because they are inconvenient and easily misplaced, and they are considered a sign of old age.
"There has been a long journey to find alternative solutions such as contact lenses or inlays, but all have problems of efficacy, safety or convenience of use. We developed a first-in-class pharmacological solution using a combination of existing molecules already used in the eye for other indications. You just put a drop in each eye and you can potentially see well for several hours. It can be very safe and convenient."
More than five years of R&D have gone into Orasis' CSF-1 patented formula. Following studies in humans in a few centers in Israel and Europe — results are soon to be published — the next step is a Phase 2b study in the United States, Kedar tells ISRAEL21c. "We have started the regulatory process," he says.
The latest funding round was led by California-based Visionary Ventures, with participation from investors including from Sequoia Capital, SBI Japan-Israel Innovation Ventures, and New York-based LifeSci Venture Partners. Visionary Ventures' Jeffry Weinhuff and SBI's Masafuyu Tanaka joined the Orasis board of directors.
NANO-DROPS: No more blurry vision
Developed at Bar-Ilan University's Institute of Nanotechnology and Advanced Materials (BINA) in Ramat Gan, Nano-Drops offers a patented solution for correcting all refractive errors that cause blurry vision – farsightedness, nearsightedness and astigmatism.
In preclinical tests using pig eyes (which are similar to human eyes), Nano-Drops achieved a correction of 3 diopters for farsightedness and 2.5 diopters for nearsightedness by locally modifying the corneal refractive index. Further fundraising, development and in vivo animal testing is coming next, followed by a human trial in late 2019.
From left, Nano-Drops developers Dr. David Smadja, Prof. Zeev Zalevsky and Prof. Jean-Paul Moshe Lellouche. Photo courtesy of Bar-Ilan University
Nano-Drops are meant to be applied in a three-step process.
First, the user measures refraction using any of several existing smartphone apps. A proprietary laser device – standalone or clipped onto a smartphone – then uses that measurement to stamp an individualized optical pattern onto the top layer of the cornea in a few milliseconds. (This is not the same as laser ablation; it is a delivery method using fast, painless pulses.)
Finally, synthetic biocompatible protein nanoparticle drops are applied to the eye to enhance and activate the stamped optical pattern. The result is a change in the refractive index and ultimately modification of the trajectory of light passing through the cornea.
"We don't know how long the effect lasts because we haven't done in vivo experiments yet," says Dr. David Smadja, an ophthalmologist at Jerusalem's Shaare Zedek Medical Center and a BINA research associate. "In January we will do in vivo tests on rabbits or pigs."
Smadja immigrated to Israel from France three and a half years ago. "I'm a physician, so I see every day what I don't have in hand to treat my patients and I'm always looking for what is missing," he tells ISRAEL21c.
"But technology is not my field, so I started working with Prof. Zeev Zalevsky [from Bar-Ilan's Kofkin Faculty of Engineering] and he makes my ideas real. We've been working on Nano-Drops for two years. Now we have many projects together."
The other partner in developing Nano-Drops is Prof. Jean-Paul Moshe Lellouche, head of the chemistry department at Bar-Ilan. The university's Birad Research & Development Company has filed a patent for Nano-Drops and is working with Nano-Drops cofounder and chief business officer Steve Elbaz to commercialize the new technology.
"In the future, this technology may enable patients to have their vision corrected in the comfort of their own home," says Smadja.
9 Suppressed Inventions That Could Have Changed The World
Here is the list of 9 Suppressed / lost inventions in history that could have changed the world. From a strange time travel machine to a mechanic who invented a water fueled car.
9. Water Fuel Cell
8. Cloud buster
6. Rife devices
5. Sloot digital coding system
4. Ogle's Carburetor
3. Greek Fire
1. Project X.A.
INNOVATIVE KNEE SURGERY IMPLANT INVENTED IN ISRAEL USED FOR THE FIRST TIME
The company ran through a few different prototypes before inventing the successful implant.BY OREN OPPENHEIM AUGUST 8, 2018
Doctors at Hadassah Hospital perform the surgery to insert Agili-C into a patient's heal. (photo credit: Courtesy)
At the beginning of August, Hadassah University Medical Center on Jerusalem's Mount Scopus successfully performed knee surgery using a new coral-based implant created by an Israeli startup.
The implant, Agili-C, was created by CartiHeal, a Kfar Saba-based startup founded by Nir Altschuler in 2009, that focuses on regenerative medicine. Agili-C, which is their flagship product, is currently undergoing clinical studies, being tested with patients around the world with their consent. Over 70 patients have been treated with the implant so far.
According to a statement from the hospital, the 30-year-old unidentified patient who received Agili-C at Hadassah had undergone multiple knee surgeries without any success. According to Dr. Adi Friedman, who performed the operation, "the transplant went smoothly, and I hope that the patient will be able to return to being fully active and to a painless life."
Friedman indicated that the success of the surgery is a good sign for the field of knee surgery in general.
"The need for an implant that leads to the regrowth of damaged cartilage is genuinely needed in the orthopedic world, and we hope that the [clinical] trail will succeed," he said in the statement, "and that the implant will be the breakthrough that we have been waiting for – for many years."
Agili-C is a cylindrical implant made from aragonite, which a specific structure of calcium carbonate derived from coral's exoskeleton. It is meant to regenerate damaged cartilage and bone for individuals with joint injuries, particularly in cases of lesions on the surface of knee joints.
Normally, cartilage cannot self-repair. "Basically, we are changing the paradigm" regarding knee surgery, Altschuler told The Jerusalem Post by phone. "Until now, it was known that cartilage cannot repair itself… [but] a small Israeli company" figured out how to solve what he called a "holy grail" of medicine.
The company ran through a few different prototypes, he said, before inventing the successful implant.
Regarding the Hadassah trial, Altschuler said that patients who consent to be a part of the study are randomly placed either in a group receiving the implant or one getting regular surgery. The first surgery in Hadassah went very well and the patient will be monitored by the clinical team. The company plans on expanding the trial to more hospitals in Israel and is already recruiting more patients.
CartiHeal hopes to gain FDA approval for commercialization of the Agili-C implant after the clinical trials are completed.
See you tomorrow
Love Yehuda Lave
Rabbi Yehuda Lave
2850 Womble Road, Suite 100-619, San Diego United States